nullary

ai.nullary/nullaryVersion 1.0.1

Negative results intelligence for drug discovery — query measured failures via MCP.

Status

Responds222 msNov 14, 2026, 13:31 UTCAnswered our handshake without sign-in.

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Last checked: Nov 14, 2026, 13:31 UTC
Latency: 222 ms
Remotes responding: 1 of 1
Sign-in: No sign-in
Hosting: Hosted outside the EU (detected)
Registry data as of: Nov 14, 2026, 21:12 UTC

Data from the official MCP Registry, checked by run.zero. How we check

Connect

Streamable HTTP

https://mcp.nullary.ai/mcpResponds222 msNov 14, 2026, 13:31 UTC

No sign-in

Claude Code

claude mcp add --transport http nullary https://mcp.nullary.ai/mcp

Claude Desktop and claude.ai

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Settings > Connectors > Add custom connector
Name: nullary
Remote MCP server URL: https://mcp.nullary.ai/mcp

Cursor

{
  "mcpServers": {
    "nullary": {
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}

VS Code

code --add-mcp '{"name":"nullary","type":"http","url":"https://mcp.nullary.ai/mcp"}'

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Tools

35 tools

Tools of nullary
	Description		Read-only	Idempotent	Open world
`get_compound`A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.	A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.	No	Yes	Yes	Yes
`get_coverage`Per-modality and per-source coverage stats (honest Phase-1 numbers).	Per-modality and per-source coverage stats (honest Phase-1 numbers).	No	Yes	Yes	Yes
`get_finding_provenance`Full provenance + detail for a single finding by id.	Full provenance + detail for a single finding by id.	No	Yes	Yes	Yes
`get_model_card`Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).	Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).	No	Yes	Yes	Yes
`get_target_landscape`Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).	Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).	No	Yes	Yes	Yes
`list_models`Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.	Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.	No	Yes	Yes	Yes
`list_top_targets`Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).	Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).	No	Yes	Yes	Yes
`search_adc_linker_failures`ADC failures attributed to linker chemistry.	ADC failures attributed to linker chemistry.	No	Yes	Yes	Yes
`search_admet_failures`Small-molecule ADMET failures.	Small-molecule ADMET failures.	No	Yes	Yes	Yes
`search_admet_failures_all_modalities`ADMET failures across ALL modalities.	ADMET failures across ALL modalities.	No	Yes	Yes	Yes
`search_ancestry_specific_failures`Ancestry-specific CRISPR failures.	Ancestry-specific CRISPR failures.	No	Yes	Yes	Yes
`search_bispecific_format_failures`Bispecific format/engineering failures.	Bispecific format/engineering failures.	No	Yes	Yes	Yes
`search_developability_failures`Antibody developability failures.	Antibody developability failures.	No	Yes	Yes	Yes
`search_drug_drug_interaction_failures`Drug-drug interaction failures.	Drug-drug interaction failures.	No	Yes	Yes	Yes
`search_failed_adcs`ADCs that failed at any stage.	ADCs that failed at any stage.	No	Yes	Yes	Yes
`search_failed_bispecifics`Bispecifics that failed at any stage.	Bispecifics that failed at any stage.	No	Yes	Yes	Yes
`search_failed_clinical_antibodies`Discontinued/terminated clinical antibodies.	Discontinued/terminated clinical antibodies.	No	Yes	Yes	Yes
`search_failed_essentiality_screens`Non-dependency / failed essentiality screens.	Non-dependency / failed essentiality screens.	No	Yes	Yes	Yes
`search_failed_guides`Failed/ineffective CRISPR guides.	Failed/ineffective CRISPR guides.	No	Yes	Yes	Yes
`search_failed_oligonucleotides`ASOs/siRNAs that failed engagement/developability.	ASOs/siRNAs that failed engagement/developability.	No	Yes	Yes	Yes
`search_failed_peptide_therapeutics`Failed peptide therapeutics.	Failed peptide therapeutics.	No	Yes	Yes	Yes
`search_failed_protacs`PROTACs that failed degradation/ternary/permeability.	PROTACs that failed degradation/ternary/permeability.	No	Yes	Yes	Yes
`search_failed_replications`Findings that failed to replicate.	Findings that failed to replicate.	No	Yes	Yes	Yes
`search_failed_selectivity`Small molecules that failed selectivity.	Small molecules that failed selectivity.	No	Yes	Yes	Yes
`search_failed_vaccines`Failed/terminated vaccines (by pathogen/indication).	Failed/terminated vaccines (by pathogen/indication).	No	Yes	Yes	Yes
`search_inactive_compounds`Inactive small-molecule compound-target pairs.	Inactive small-molecule compound-target pairs.	No	Yes	Yes	Yes
`search_indication_history`ALL failed approaches for an indication across every modality.	ALL failed approaches for an indication across every modality.	No	Yes	Yes	Yes
`search_mechanism_failures`Approaches that failed for a mechanism (by target).	Approaches that failed for a mechanism (by target).	No	Yes	Yes	Yes
`search_oligo_delivery_failures`Oligonucleotide delivery failures.	Oligonucleotide delivery failures.	No	Yes	Yes	Yes
`search_pathogen_history`Vaccine + antimicrobial + antibody failures for a pathogen.	Vaccine + antimicrobial + antibody failures for a pathogen.	No	Yes	Yes	Yes
`search_peptide_stability_issues`Peptide stability/half-life failures.	Peptide stability/half-life failures.	No	Yes	Yes	Yes
`search_protac_e3_issues`PROTAC E3-ligase recruitment / ternary failures.	PROTAC E3-ligase recruitment / ternary failures.	No	Yes	Yes	Yes
`search_safety_failures`Clinical/preclinical safety failures across modalities.	Clinical/preclinical safety failures across modalities.	No	Yes	Yes	Yes
`search_target_history`ALL failed approaches against a target across every modality.	ALL failed approaches against a target across every modality.	No	Yes	Yes	Yes
`search_vaccine_immunogenicity_failures`Failed vaccine immunogen designs.	Failed vaccine immunogen designs.	No	Yes	Yes	Yes

Details

Registry status: Active
Published: May 25, 2026
Updated: May 25, 2026
Website: Not given
Repository: https://github.com/nullary-ai/nullary⁠ (opens in a new tab)
Categories: Uncategorized
GDPR: Not declared

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